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Research Interests

Functionalized Soft Electrode based on Conducting Polymers

​導電高分子作為軟性功能性電極

The design and synthesis of conducting polymers as multi-functional soft electrodes.

實驗室的研究包含了以功能性導電高分子為主之軟性電極製備以及應用。

Integration of Electrochemical Techniques & Surface Analysis  

​電化學與表面分析技術整合

The integration of electrochemical techniques and surface analysis for advanced material characterization.

整合電化學與表面分析技術（如原子力顯微鏡、表面增強拉曼散射以及石英晶體微天平）進行材料分析。

Surface and Mechanical Analysis of Biomaterials at Nanoscale

生物材料在奈米尺度之表面及機械性質分析

Focused on the surface and mechanical analysis of biomaterials in liquid phase at nanoscale. 

生物材料在水相中，進行奈米尺度之表面及機械性質分析。

​Publications

  1. Jing-Ju Huang, Hsing-An Lin,* Chi Chen, Po-Wen Tang and Shyh-Chyang Luo* “Corannulene-Based Donor-Acceptor-Type Conjugated Polymers with Electrochromic Properties” Journal of Materials Chemistry C, 2021, 9, 7919-7927. 

  2. He-Chun Chou, Wei-Chieh Hsu, Yajing Yang, Kirk S. Schanze,* Shyh-Chyang Luo,* Chi Chen* “Real-Time Spectral Evolution of Interchain Coupling and Assembling during Solvent Vapor Annealing of Dispersed Conjugated Polymers” Macromolecular Chemistry and Physics, 2021, 2100135.

  3. Chia-Hui Tseng, Hsun-Hao Lin, Cheng-Wei Hung, I-Chung Cheng, Shyh-Chyang Luo*, I-Chun Cheng, and Jian-Zhang Chen* “Electropolymerized Poly(3,4-ethylenedioxythiophene)/Screen-Printed Reduced Graphene Oxide–Chitosan Bilayer Electrodes for Flexible Supercapacitors” ACS Omega 2021, 6, 16455–16464.

  4. 吳致廣、林家萱、羅世強*「導電高分子於現在醫療之應用」台灣化學工程學會會刊 2021, 68, 66-81.

  5. Mei-Hwa Lee, Kuan-Ting Liu, James L. Thomas, Zi-Lin Su, Danny OHare, Thea van Wuellen, Jennifer Modamio Chamarro, Silvia Bolognin, Shyh-Chyang Luo,* Jens C. Schwamborn,* Hung-Yin Lin* “Peptide-Imprinted Poly(hydroxymethyl 3,4-ethylenedioxythiophene) Nanotubes for Detection of  Synuclein in Human Brain Organoids” ACS Applied Nano Materials, 2020, 3, 8027–8036.

  6. Mi Chin,  Seiichi Tada, Min-Han Tsai, Yoshihiro Ito* and Shyh-Chyang Luo* “Strategy to Immobilize Peptide Probe Selected through in Vitro Ribosome Display for Electrochemical Aptasensor Application” Analytical Chemistry, 2020, 92, 11260-11267.

  7. Jhih-Guang Wu, Shu-Chen Wei, and Shyh-Chyang Luo “In Situ Probing Unusual Protein Adsorption Behavior on Electrified Zwitterionic Conducting Polymers” Advanced Materials Interfaces, 2020, 7, 2000470.

  8. Yow-Kuan Lin, Ruo-Ju Tai, Shu-Chen Wei* and Shyh-Chyang Luo* “Electrochemical SERS on 2D Mapping for Metabolites Detection” Langmuir, 2020, online.

  9. Ya-Qiong Zhang, Hsing-An Lin, Qi-Chao Pan, Si-Hao Qian, Shu-Hua Zhang, Gao Qiu, Shyh-Chyang Luo, Hsiao-hua Yu, Bo Zhu “Tunable Protein/Cell Binding and Interaction to Neurite Outgrowth of Low-Impedance Zwitterionic PEDOTs” ACS Applied Materials & Interfaces, 2020, 12, 12362-12372.

  10. Masaru Mukaia, Chao-Hung Cheng, Wei Ma, Mi Chin, Chia-Hsin Lin, Shyh-Chyang Luo and Atsushi Takahara “Synthesis of Conductive Polymer Thin Film Having Choline Phosphate Side Group and Their Bioadhesive Properties” Chemical Communications, 2020, 56, 2691-2694. 

  11. Tharwat Hassan Mansoure, Hailemichael Ayalew, Wei-Lun Kao, Jing-Jong Shyue, Shyh-Chyang Luo, Yuan-Chung Cheng, and Hsiao-hua Yu “Perfluoro-Functionalized Conducting Polymers Enhance Electrocatalytic Oxygen Reduction” ACS Applied Energy Materials, 2020, 3, 1171-1180.

  12. Bor-Shiunn Lee, Yi-Chen Lin, Wei-Chieh Hsu, Cheng-Hung Hou, Jing-Jong Shyue, Shu-Yun Hsiao, Pei-Ju Wu, Ying-Te Lee and Shyh-Chyang Luo “Engineering Antifouling and Antibacterial Stainless Steel for Orthodontic Appliances through Layer-by-Layer Deposition of Nanocomposite Coatings” ACS Applied Bio Materials, 2020, 3, 486-494.

  13. Bo-Chang Lai, Jhih-Guang Wu and Shyh-Chyang Luo “Revisiting Background Signals and the Electrochemical Windows of Au, Pt, and GC Electrodes in Biological Buffers” ACS Applied Energy Materials, 2019, 2, 6808-6816.

  14. Jhih-Guang Wu, Jie-Hao Chen, Kuan-Ting Liu, and Shyh-Chyang Luo “Engineering Antifouling Conducting Polymers for Modern Biomedical Applications” ACS Applied Materials & Interfaces, 2019, 11, 21294-21307.

  15. Min-Han Tsai, Yow-Kuan Lin, Shyh-Chyang Luo “Electrochemical SERS for in Situ Monitoring the Redox States of PEDOT and Its Potential Application in Oxidant Detection” ACS Applied Materials & Interfaces, 2019, 11, 1402-1410.

  16. Chia-Yu Lin, Shyh-Chyang Luo, Jia-Shing Yu, Ta-Ching Chen, Wei-Fang Su “Peptide-Based Polyelectrolyte Promotes Directional and Long Neurite Outgrowth” ACS Applied Bio Materials, 2019, 2, 518-526.

  17. Yue Chen and Shyh-Chyang Luo “Synergistic Effects of Ions and Surface Potentials on Antifouling Poly(3,4-ethylenedioxythiophene): Comparison of Oligo(Ethylene Glycol) and Phosphorylcholine” Langmuir 2019, 35 , 1199-1210.

  18. Po-Chun Huang, Mo-Yuan Shen, Hsiao-hua Yu, Shu-Chen Wei, and Shyh-Chyang Luo “Surface Engineering of Phenylboronic Acid-Functionalized Poly(3,4-ethylenedioxythiophene) for Fast Responsive and Sensitive Glucose Monitoring” ACS Applied Bio Materials, 2018, 1, 160-167. 

  19. Hsing-An Lin, Bo Zhu, Yu-Wei Wu, Jun Sekine, Aiko Nakao, Shyh-Chyang Luo, Yoshiro Yamashita and Hsiao-hua Yu “Dynamic Poly(3,4-ethylenedioxythiophene)s Integrate Low Impedance with Redox-switchable Biofunction” Advanced Functional Materials, 2018, 1703890.

  20. Jhih-Guang Wu, Shu-Chen Wei, Yue Chen, Jie-Hao Chen and Shyh-Chyang Luo “Critical Study of the Recognition between C-Reactive Protein and Surface-Immobilized Phosphorylcholine by Quartz Crystal Microbalance with Dissipation” Langmuir 2018, 34, 943-951.

  21. Zhen-Hua Wang, Yen-Yu Chang, Jhih-Guang Wu, Chia-Yu Lin, Hsiao-Lung An, Shyh-Chyang Luo, Tang K. Tang and Wei-Fang Su “Novel 3D Neuron Regeneration Scaffolds Based on Synthetic Polypeptide Containing Neuron Cue” Macromolecular Bioscience 2017, 1700251.

  22. Shyh-Chyang Luo; James L. Thomas, Han-Zhang Guo, Wei-Tang Liao, Mei-Hwa Lee, Hung-Yin Lin “Electrosynthesis of Nanostructured, Imprinted Poly(hydroxymethyl 3,4-ethylenedioxy thiophene) for the Ultrasensitive Electrochemical Detection of Urinary Progesterone” ChemistrySelect, 2017, 2, 7935-7939.

  23. Jhih-Guang Wu, Cheng-Yang Lee, Shao-Shuo Wu, Shyh-Chyang Luo “Ionic Liquid-Assisted Electropolymerization for Lithographical Perfluorocarbon Deposition and Hydrophobic Patterning” ACS Applied Materials & Interfaces, 2016, 8, 22688-22695.

  24. Chien-Hsun Chen, Shyh-Chyang Luo “Tuning Surface Charge and Morphology for the Efficient Detection of Dopamine under the Interferences of Uric Acid, Ascorbic Acid, and Protein Adsorption” ACS Applied Materials & Interfaces, 2015, 7, 21931-21938.

  25. Ke, Z. F.; Lin, M.; Chen, J. F.; Choi, J. S.; Zhang, Y.; Fong, A.; Liang, A. J.; Chen, S. F.; Li, Q. Y.; Fang, W. F.; Zhang, P. S.; Garcia, M. A.; Lee, T.; Song, M.; Lin, H. A.; Zhao, H. C.; Luo, S. -C.; Hou, S.; Yu, H. H.; Tseng, H. R. “Programming Thermoresponsiveness of Nano Velcro Substrates Enables Effective Purification of Circulating Tumor Cells in Lung Cancer Patients” ACS Nano, 2015, 9, 62-70.

  26. Sivashanmugana, K.; Liao, J. -D.; Bernard Liu, H.; Yao, C. -K; Luo, S. -C. “Ag nanoclusters on ZnO nanodome array as hybrid SERS-active substrate for trace detection of malachite green” Sensors and Actuators B: Chemical, 2015, 207, 430-436.

  27. Lee, J. -E.; Luo, S. -C.; Zhu, B.; Park, J. W.; Yu, H. -h. " Nanoscale Analysis of Functionalized Polythiophene Surfaces: the Effect of Electropolymerization Methods and Thermal Treatment " RSC Advances, 2014, 4, 62666.

  28. Zhu, B.; Luo, S. -C.; Zhao, H.; Lin, H. -A; Sekine, J.; Nakao, A.; Chen, C.; Yamashita Y.; Yu, H. -h. “Large Enhancement of Neurite Outgrowth on a Cell-Membrane Mimicking Conducting Polymer” Nature Communications, 2014, 5, 4523.

  29. Lee, J.-E.; Kwak, J. -W.; Park, J. W.; Luo, S. -C.; Zhu, B.; Yu, H. -h. "Nanoscale Analysis of a Functionalized Polythiophene Surface by Adhesion Mapping" Analytical Chemistry, 2014, 86, 6865-6871.

  30. Luo, S. -C.; Sivashanmugan, Kundan; Liao, Jiunn-Der; Yao, Chih-Kai Yao; Peng, Han-Chi “Nanofabricated SERS-active substrates for single-molecule to virus detection in vitro: a review” Biosensors & Bioelectronics, 2014, 61, 232-240.

  31. Hsiao, Y. -S.; Luo, S. -C.; Hou, S.; Zhu, B.; Sekine, J.; Kuo, C. -W.; Chueh, D. -Y.; Yu, H. -h.; Tseng, H. -R.; Chen, P. “3D Bioelectronic Interface- Capturing Circulating Tumor Cells onto Conducting Polymer-Based Micro-Nanorod Arrays with Chemical and Topographical Control” Small, 2014, 10, 3012-3017.

  32. Li, Z.; Uzawa, T.; Zhao, H.; Luo, S. -C.; Yu, H. -h.; Kobatake, E.; Ito, Y. “In vitro Selection of Peptide Aptamers Using a Ribosome Display for a Conducting Polymer” Journal of Bioscience and Bioengineering, 2013, 501-503.

  33. Narayanan, K.; Lim, V. Y.; Shen, J.; Tan, Z. W.; Rajendran, D.; Luo, S. -C.; Gao, S.; Wan, A. C. A.; Ying, J. Y. “Extracellular Matrix-Mediated Differentiation of Human Embryonic Stem Cells” Tissue Engineering, 2014, 20, 424-433.

  34. Luo, S. -C. “Conducting Polymers as Biointerfaces and Biomaterials: A Perspective for a Special Issue of Polymer Reviews” Polymer Reviews, 2013, 53, 303-310.

  35. Zhao, H.; Zhu, B.; Luo, S. -C.; Lin, H. -A; Nakao, A.; Yamashita, Y.; Yu, H. -h. “Controlled Protein Absorption and Cell Adhesion on Polymer Brushes Grafted Poly(3,4- ethylenedioxythiophene) Films” ACS Applied Materials & Interfaces, 2013, 5, 4536-4543.

  36. Lin, H. -A.; Luo, S. -C.; Zhu, B.; Chen, C.; Yamashita, Y.; Yu, H. -h. “Molecular or Nanoscale Structures? The Deciding Factor of Surface Properties on Functionalized Poly(3,4- ethylenedioxythiophene) Nanorod Arrays” Advanced Functional Materials, 2013, 23, 3212- 3219.

  37. Hou, S.; Zhao, H.; Zhao, L.; Shen, Q.; Wei, K. S.; Suh, D. Y.; Nakao, A.; Garcia, M. A.; Song, M.; Lee, T; Xiong, B.; Luo, S. -C.; Tseng, H. -R.; Yu, H. -h. “Capture and Stimulated Release of Circulating Tumor Cells on Polymer Grafted Silicon Nanostructures” Advanced Materials, 2013, 25, 1547-1551.

  38. Zhao, H; Liu, C. -Y; Luo, S. -C.; Zhu, B.; Wang, T. -H.; Hsu, H. -F.; Yu, H. -h. “Facile Syntheses of Dioxythiophene-Based Conjugated Polymers by Direct C-H Arylation" Macromolecules, 2012, 45, 7783-7790.

  39. Lacher, S.; Obata, N.; Luo, S. -C.; Matsuo, Y.; Zhu, B.; Yu, H. -h.; Nakamura, E. “Electropolymerized Conjugated Polyelectrolytes with Tunable Work Function and Hydrophobicity as an Anode Buffer in Organic Optoelectronics” ACS Applied Materials & Interfaces, 2012, 4, 3396-3404.

  40. Luo, S. -C.; Sekine, J.; Zhu, B.; Zhao, H.; Nakao, A.; Yu, H. -h. “Polydioxythiophene Nanodots, Nanowires, Nano-Networks, and Tubular Structures: The Effect of Functional Groups and Temperature in Template-Free Electropolymerization” ACS Nano, 2012, 6, 3018-3026.

  41. Luo, S. -C.; Kantchev, E. A. B.; Zhu, B.; Siang, Y. W.; Yu, H. -h. “Tunable, Dynamic and Electrically Stimulated Lectin-Carbohydrate Recognition on a Glycan-Grafted Conjugated Polymer” Chemical Communications 2012, 48, 6942-6944.

  42. Zhao, H.; Zhu, B.; Sekine, J.; Luo, S. -C.; Yu, H. -h. “Oligoethylene-Glycol-Functionalized Polyoxythiophenes for Cell Engineering: Syntheses, Characterizations, and Cell Compatibilities” ACS Applied Materials and Interfaces, 2012, 4, 680-686.

  43. Sekine, J.; Luo, S. -C.; Zhu, B.; Wang, S. T.; Tseng H. -R.; Yu, H.-h. “Functionalized Conducting Polymer Nanodots for Enhanced Cell Capturing: the Synergistic Effect of Capture Agents and Nanostructures” Advanced Materials, 2011, 24, 4788-4792.

  44. Luo, S. -C.; Zhu, B.; Nakao, A.; Nakatomi, R.; Yu, H. -h. “Functionalized Conducting Polymer Nano-Networks from Controlled Oxidation Polymerization toward Cell Engineering” Advanced Engineering Materials, 2011, 13, B423-B427.

  45. Luo, S. -C.; Liour, S. S.; Yu, H. -h. “Perfluoro-functionalized PEDOT films with controlled morphology as superhydrophobic coatings and biointerfaces with enhanced cell adhesion” Chemical Communications, 2010, 46, 4731-4733.

  46. Xie. H.;Luo, S. -C.; Yu, H.-h. “Electric-Field Assisted Growth of Functionalized Poly(3,4-ethylenedioxythiophene) Nanowires for Label-free Protein Detection” Small, 2009, 5, 2611. 

  47. Luo, S. -C.; Chen, N.; Xie, H.; Yu, H.-h.; Ying, J. Y. “Trinity DNA detection on oligonucleotide-grafted PEDOT nanobiointerfaces” ACS Applied Materials and  Interfaces, 2009, 1, 1414-1419. 

  48. Luo, S. -C.; Jiang, J.; Liour, S. S.; Gao, S.;Ying, J. Y.; Yu, H. -h. “Magnetic Single-Hole PEDOT Hollow Spheres” Chemical Communication 2009, 21, 2664-2666.

  49. Shi, Y.;Luo, S. -C.; Fang, W.; Zhang, K.; Ali, E. M.; Boey, F. Y. C.; Ying, J. Y.; Wang, J.; Yu, H. -h., Li, L.-J. “Work function engineering of electrodes via electropolymerization of ethylenedioxythiophenes and its derivatives” Organic Electronics 2008, 9, 859-863. 

  50. Luo, S. -C.; Wan, A. C. A.; Han, Y.; Yu, H. -h., Ying, J. Y. “A general route for functional PEDOT coating on non-conductive surface and hollow particles with single hole via aqueous chemical polymerization” Small, 2008, 4, 2051-2058. 

  51. Luo, S. -C.; Ali, E. M.; Tansil, N. C.; Yu, H. -h.; S. Gao, Kantchev, E. A. B.; Ying, J. Y. “PEDOT nanobiointerfaces: thin, ultrasmooth, and functionalized poly(3,4-ethylenedioxythiophene) films with in vitro and in vivo biocompatibility” Langmuir 2008, 24, 8071-8077. 

  52. Luo, S. -C.; Douglas, E. P. “Rupture Conjugated Polymer Thin Films Formed during Spin-Coating”: Journal ofPolymer Science, Part B: Polymer Physics. 2006, 44, 79. 

  53. Luo, S. -C.; Craciun, V.; Douglas, E. P. “Instabilities during Formation of Electro-active Polymer Thin Films”, Langmuir 2005, 21, 2881. 

  54. Luo, S. -C.; Chung, H. -H.; Pashuck, E. T.; Douglas, E. P.; Holloway, P. H. “Formation of Bubbles on Electrical Contacts to Polymer Light-emitting Diode Devices”, Thin Solid Films 2005, 478, 326.

  55. Li, Y. J.; Kwon, Y. W.; Jones, M.; Heo, Y. W.; Zhou, J.; Luo, S. -C.; Holloway, P. H.; Douglas, E. P.; Norton, D. P. "Progress in semiconducting oxide-based thin film transistors for organic light emitting diode displays", Semiconductor Science and Technology, 2005, 20, 720.

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